Physician Profile

Patrick B. Senatus, M.D., Ph.D.

Dr. Senatus is an assistant professor of surgery in the Division of Neurosurgery and Department of Neuroscience at the University of Connecticut Health Center. He received his B.A. in biochemical Sciences, Ph.D. in neurobiology, and M.D. from Harvard University. He completed his neurosurgery residency at New York-Presbyterian Hospital of Columbia University Medical Center, where he served as chief resident. Dr. Senatus subsequently attended the Cleveland Clinic Foundation where he completed a fellowship in functional and restorative neurosurgery. He is especially interested in deep brain and spinal cord stimulation for the treatment of movement disorders. In addition, Dr. Senatus manages patients with acute neck and back pain.

Appointment

• Assistant Professor, Division of Neurosurgery, University of Connecticut Health Center
• Assistant Professor, Department of Neuroscience, University of Connecticut Health Center
• Director, Functional Neurosurgery, University of Connecticut Health Center
• Comprehensive Spine Center, New England Musculoskeletal Institute

Specialty

• Functional and Restorative Neurosurgery
• Spine Surgery

Subspecialty

• Spinal Cord, Peripheral nerve, and Deep Brain Stimulation
• Intrathecal medication infusion
• Computer-guided stereotactic neurosurgery
• Cervical and lumbar decompression and fusion

Certifications
National Board of Medical Examiners
American Board of Neurological Surgery Board Eligibility

Education
B.A., Biochemical Sciences, Harvard College, Harvard University
M.D., Harvard Medical School, Harvard University
Ph.D., Harvard Graduate School of Arts and Sciences, Harvard University

State Licensure
Connecticut
Ohio
New York

Residency
Columbia University, Dept. of Neurological Surgery, New York-Presbyterian Hospital

Fellowship
Cleveland Clinic Foundation, Center for Neurological Restoration

Awards
American Brain Tumor Association Fellowship
Medical Scientist Training Program Fellowship
Harvard University Graduate Prize Fellowship
Association for Academic Surgery Award
National Medical Association Merit Award
American Federation for Clinical Research Medical Student Award

Selected Publications
McClelland S.III, Senatus P.B., Ford B., McKhann II G., Goodman R.R. Staged bilateral thalamic electrode implantation utilizing frameless stereotactic guidance. J. Clin Neurosci. 2007 Aug;14(8):791-3.

Senatus P.B., Teeple D., McClelland S. 3rd, Pullman S.L., Yu Q., Ford B., McKhann G.M. 2nd, Goodman R.R. A technique for minimally altering anatomically based subthalamic electrode targeting by microelectrode recording. Neurosurg Focus. 2006 May 15;20(5):E8.

Senatus P.B., Li Y., Mandigo C., Nichols G., Moise G., Mao Y., Brown M.D., Anderson R.C., Parsa A.T., Brandt-Rauf P.W., Bruce J.N., Fine R.L. Restoration of p53 function for selective Fas-mediated apoptosis in human and rat glioma cells in vitro and in vivo by a p53 COOH-terminal peptide. Molecular Cancer Therapeutics 5 (1): 20-8 January 2006.

Senatus P.B., McClelland S.III, Teeple D., Qureshi I., McKhann II G., Pullman S., Yu Q., Ford B., Goodman R. The Effects of Microelectrode Recording on Anatomically Based Subthalamic Nucleus Deep Brain Stimulating Electrode Targeting. Neurosurgical Focus 20 (5): E8, 2006.

Goodman R.R., Kim B., McClelland S.III, Senatus P.B.,Winfield L.M., Pullman S.L., Yu Q., Ford B., McKhann G.M. II.Operative Techniques and Morbidity with Subthalamic Nucleus Deep Brain Stimulation in 100 Consecutive Patients with Advanced Parkinson Disease. Journal of Neurology, Neurosurgery, 77(1): 12-17, 2006.

Senatus P.B., McClelland S.III, Tanji K., Khandji A., Huang J., Feldstein N.: " The Transformation Pediatric Gliomatosis Cerebri to Cerebellar Glioblastoma Multiforme Presenting as Supra and Infratentorial Acute Disseminated Encephalomyelitis: A Case Report" Journal of Neurosurgery: Pediatrics 102(1): 72-77, 2005.

McClelland S.III, Ford B., Senatus P.B., Winfield L.M., Du Y.E., Pullman S.L., Yu Q., Frucht S.J., McKhann G.M. II,Goodman R.R. Subthalamic Stimulation for Parkinson Disease: Determination of Electrode Location Necessary For Clinical Efficacy. Neurosurgical Focus, 19(5): E12, 2005.

Laurencin C.T., Senatus P.B. and Lipson S.J. (1995) Massive destructive lumbar discitis in rheumatoid arthritis. NeuroOrthopaedics 19: 45-52.

Laurencin C.T., Senatus P.B., Botchay E., Korris M., Hunter J. and Lipson S.J. (1995) The stenosis ratio: A new tool for the diagnosis of degenerative spinal stenosis. Int J. Surg Investigation 1999; 1(2): 127-31.

View more publications, see Pubmed listing.

Research Interests
Dr. Senatus’ research interests encompass the investigation and development of novel neurosurgical approaches to intractable neurological and neuropsychiatric disorders. Employing the techniques of in vitro and in vivo electrophysiology, Dr. Senatus seeks to examine the cellular and systems-level correlates of central nervous system functional pathology.