Physician Profile

Pamela Taxel, M.D.

Dr. Taxel is an associate professor of medicine in the Division of Endocrinology and Metabolism at the University of Connecticut Health Center. She specializes in the treatment of patients with osteoporosis, and has a special interest in developing treatment regimens for men with osteoporosis.

Appointment

• Associate Professor of Medicine, Division of Endocrinology and Metabolism, UConn Health Center

Specialty

• Endocrinology
• Geriatrics

Subspecialty

• Osteoporosis (particularly in men) with emphasis on hormonal manipulation in disease models such as prostate and breast cancer

Certifications
American Board of Internal Medicine
American Board of Internal Medicine: Endocrinology and Metabolism
American Board of Internal Medicine: Geriatrics

Education
B.S., University of Pennsylvania
M.A., New York University
M.D., State University of New York, (Downstate)

State Licensure
Connecticut
Florida

Residency
University of South Florida
University of Connecticut School of Medicine

Fellowship
University of Connecticut School of Medicine

Selected Publications
Peer-reviewed publications.

Taxel, P.*, Prestwood, K. Estrogen for the prevention and treatment of osteoporosis: intervention in the older woman, The Endocrinologist, 1996, 6(3): 179-185.

Taxel, P.*, Waitzman D., Rothfield N., Malchoff C. Chiasmal herniation as a complication of bromocriptine treatment, Journal of Neuro-ophthalmology, 1996, 16(4): 252 - 257.

Advani, S., Bogdanovic, E., LaFrancis, D., Taxel, P., Kream, B., Raisz, L.G., Dexamethasone suppresses in vivo bone matrix synthesis and gene expression in neonatal mice. Bone, 1997, 20(1): 41-46.

Giri S., Thompson P.D., Taxel P., Contois J.H., Otvos J., Allen R., Ens G., Wu A.H., Waters D.D. Oral estrogen improves serum lipids, homocysteine and fibrinolysis in elderly men. Atherosclerosis, 1998, 137: 359-66.

Taxel P.*, Kennedy D., Fall P., Willard A., Shoukri K., Clive J., Raisz L.G., The effect of short-term treatment with micronized estradiol on bone turnover in older men with low bone mass. 2000 Endocrine Research, 26:381-98.

Taxel P.*, Kennedy D.G., Fall P.M., Willard A.K., Clive J.M., Raisz L.G. The effect of aromatase ihibition on sex steroids, gonadotropins and markers of bone turnover in older men. Jour Clin Endocrinol Metab 2001, 86: 2869-74.

Taxel P.*, Albertsen P.C., Dowsett R., Fall P.M., Trahiotis M., Zimmerman J., Ohanessian C., Raisz L.G. The effect of micronized estradiol on bone turnover and calciotrophic hormones in older men receiving hormonal suppression for prostate cancer. Jour Clin Endocrinol Metab. 2002, 87:4907-4913.

Chakraborty N.G., Stevens R.L., Laska E., Taxel P., Sporn J.R., Schauer P., Albertsen P.C. Recognition of PSA derived peptide antigens by t cells from prostate cancer patients without any prior stimulation. Cancer Immunol Immunother, 2003; 52: 497-505.

Taxel P.*, Stevens M.C., Trahiotis M., Zimmerman J., Kaplan R.F. The effect of short-term estradiol therapy on cognitive function in older men receiving hormonal suppression therapy for prostate cancer. J Am Geriatr Soc. 2004;52(2):269-73.

Taxel P.*, Fall P.M., Prestwood K.M., Dulipsingh L., Raisz L.G. Evaluation of helical peptide, a new marker of bone resorption. Clin Chem. 2004;50(4):747-50.

Joseph C., Kenny A.M., Taxel P., Lorenzo J.A., Duque G., Kuchel G.A. Role of endocrine-immune dysregulation in osteoporosis, sarcopenia, frailty and fracture Risk. Mol Aspects Med. 2005;26(3):181-201.

Boxer R.S., Kenny A.M., Dowsett R., Taxel P. The effect of 6 months of androgen deprivation therapy on muscle and fat mass in older men with localized prostate cancer. Aging Male. 2005;8(3):207- 12.

Invited Reviews

Taxel, P.* Oral agents can play key role in type II diabetes management. Diabetes in the News, 1994.

Taxel P.* “Osteoporosis: Detection, prevention and treatment in primary care.” Geriatrics, 1998; 53: 22-40.

Taxel P.*, Kenny A. Differential diagnosis and secondary causes of osteoporosis. Clinical Cornerstone 2: 11-21, 2000.

Kenny A., Taxel P. Osteoporosis in older men. Clinical Cornerstone. 2: 45-51, 2000.

Yang S, Taxel P*. Male osteoporosis: An emerging clinical problem. Clinical Geriatrics. 2002, 10: 28-37.

Kenny A.M., Joseph C., Taxel P., Prestwood K.M. Osteoporosis in older men and women. Conn Med. 2003;67(8):481-6.

Sayed Y., Taxel P.*, The use of estrogen therapy in men. Curr Opin Pharmacol. 2003;3(6):650-4.

Coll P.P., Taxel P. The Management of Thyroid Disorders in Long-Term Care. Annals of Long-Term Care: Clinical Care and Aging 2004; 12(3): 26-30.

Sucich M., Taxel P.* Osteoporosis in Aging Men, In Aging Men’s Health: A Case-Based Approach. Theme Medical Publishers : Medical Publications, Robert S. Tan, M.D. (editor), 2005.

View more publications, see Pubmed listing.

Research Interests

Clinical Research

• The role of estrogen on bone metabolism in older men and women.
• The effect of aromatase inhibitors on markers of bone turnover and bone density in women with breast cancer.
• The effect of androgen deprivation therapy on bone in men with prostate cancer.